Is Citrulline Supplementation Worth It?

Citrulline (commonly taken as citrulline malate) is known for its performance-enhancing potential. However, the literature on citrulline is mixed, with some studies showing benefit, and others not. Paradoxically, this occurs despite similar citrulline doses (8 grams) and timing (~30-60 minutes pre-workout) across studies.

Luckily, Trexler et al.’s 2019 meta-analysis clarifies citrulline’s role in performance. In this analysis of 12 studies, citrulline modestly improved strength endurance (based on 8 studies), while marginally enhancing power outcomes.